The early 1900s Spanish Flu hardly killed anyone. Instead, the victims killed themselves, with an immune overreaction. They went into a positive feedback loop until they broke. (Tangent: probably due to either malnutrition or iatrogenic pathology.)
The early 2000s just-a-flu hardly killed anyone. Instead, the victims were killed by a government overreaction. Instead of merely individual victims succumbing to their own self-hatred, whole societies were convulsed by self-destructive positive feedback loops which tried to inflict the hatred on everyone stupid enough to listen to their government. It continued until the feedbacks broke themselves.
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